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Bupropion, the chemical name for this medication, is additionally sold under the brand name zyban to help stop the urge to smoke.
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in a clinical trial of 15 male subjects ages 19 to 35 years who were extensive metabolizers of cyp2d6, bupropion 300 mg per day followed by a single dose of 50 mg desipramine increased the c max , auc, and t 1 2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively.
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cases of suicidal ideation and suicidal behaviour have been reported during bupropion therapy see section 4.
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mao inhibitors – do not combine cyp2b6 inhibitors and inducers – bupropion is a cyp2b6 sensitive substrate cyp2d6 substrates – bupropion is a cyp2d6 strong inhibitor oct2 substrates – bupropion is an oct2 inhibitor amantadine – may increase side effects clopidogrel plavix – clopidogrel is a cyp2b6 inhibitor and may raise bupropion levels.
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according to the manufacturer of wellbutrin, drinking excessive amounts or abruptly withdrawing from alcohol after chronic use may increase the risk of seizure event in patients taking bupropion.
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