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Assuming no extrahepatic metabolism, the model-predicted contribution of cyp3a to net intrinsic clearance should equal the fractional decrement in apparent oral clearance of amitriptyline upon complete inhibition of the enzyme.
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for the treatment of chronic pain states, amitriptyline should be started at a dosage of 10 to 25 mg day and increased by 10 to 25 mg week to the maximum suggested or tolerated dosage.
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amitriptyline was discovered in 1960 7 and approved by the us food and drug administration fda in 1961.
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