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before taking this medication, tell your doctor if you are taking any of the following medicines tricyclic antidepressants such as amitriptyline elavil, endep ; or doxepin sinequan ; , which may decrease the effects of chlorthalidone and reserpine; other commonly used tricyclic antidepressants, including amoxapine ascendin ; , clomipramine anafranil ; , desipramine norpramin ; , imipramine tofranil ; , nortriptyline pamelor ; , and protriptyline vivactil digoxin lanoxin ; or quinidine cardioquin, quinidex, quinora, quinaglute ; , which will increase the risk that you will experience an irregular heartbeat when it is taken with chlorthalidone and reserpine; barbiturates such as phenobarbital luminal, solfoton ; , amobarbital amytal ; , and secobarbital seconal ; , which may cause extreme sleepiness or dizziness if taken with chlorthalidone and reserpine; narcotic pain relievers such as codeine tylenol 3, tylenol 4, others about others , propoxyphene darvon, darvocet, wygesic ; , oxycodone percodan, percocet, tylox ; , meperidine demerol ; , morphine ms contin, duramorph, others ; , and others also may cause extreme sleepiness or dizziness if taken with chlorthalidone and reserpine; steroid medications such as hydrocortisone hydrocortone, cortef ; , prednisone deltasone, orasone ; , prednisolone delta cortef, prelone ; , methylprednisolone medrol ; , betamethasone celestone ; , dexamethasone decadron, hexadrol ; , and others, which may increase the side effects of chlorthalidone; prescription and over-the-counter cough, cold, allergy, diet, and sleeping pills, any of which may contain drugs that increase your blood pressure and heart rate and thus decrease the effects of reserpine; the cholesterol-lowering drugs cholestyramine questran ; and colestipol colestid ; , which may decrease the effects of; nonsteroidal anti-inflammatory drugs nsaids ; such as ibuprofen motrin, advil ; , ketoprofen orudis, orudis about orudis ; , kt, oruvail ; , and naproxen naprosyn, anaprox, aleve ; , which may also decrease the effects of chlorthalidone; other commonly usednsaids see also nsaids ; , including diclofenac cataflam, voltaren ; , etodolac lodine ; , fenoprofen nalfon ; , flurbiprofen ansaid ; , indomethacin indocin ; , ketorolac toradol ; , mefenamic acid ponstel ; , nabumetone relafen ; , oxaprozin daypro ; , piroxicam feldene ; , sulindac clinoril ; , and tolmetin tolectin oral antidiabetic drugs such as glipizide glucotrol ; , glyburide micronase, glynase, diabeta ; , chlorpropamide diabinese ; , tolazamide tolinase ; and tolbutamide orinase ; , which may not lower your blood sugar as well your diabetes therapy may have to be adjusted lithium lithobid, eskalith ; , should not be taken with chlorthalidone because serious side effects may result; or other drugs that also lower blood pressure, including acebutolol sectral ; , atenolol tenormin ; , bisoprolol zebeta ; , carteolol cartrol ; , labetalol trandate, normodyne ; , propranolol inderal ; , pindolol visken ; , timolol blocadren ; , benazepril lotensin ; , enalapril vasotec ; , captopril capoten ; , fosinopril monopril ; , lisinopril prinivil, zestril ; , moexipril univasc ; , quinapril accupril ; , ramipril altace ; , amlodipine norvasc ; , bepridil vascor ; , diltiazem cardizem, dilacor ; , felodipine plendil ; , isradipine dynacirc ; , nicardipine cardene ; , nifedipine adalat, procardia ; , nimodipine nimotop ; , and verapamil calan, verelan, isoptin.
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the mechanism of action of indocin, like that of other nsaids, is not completely understood but involves inhibition of cyclooxygenase cox-1 and cox-2 .
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