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John s wort because they may decrease atorlip-5 s effectiveness digoxin, hormonal contraceptives eg, birth control pills , macrolide immunosuppressants eg, tacrolimus , or spironolactone because the risk of their side effects may be increased by atorlip-5.
Our findings suggest that, in patients with af, digoxin is associated with increased all-cause mortality after controlling for comorbidities and propensity scores, regardless of gender and the presence or absence of underlying hf.
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Altretamine moderate some antineoplastic agents have been reported to decrease the absorption of digoxin tablets due to their adverse effects on the gi mucosa; the effect on digoxin liquid is not known.
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Simvastatin increases the effect of warfarin coumadin and the blood concentration of digoxin lanoxin .
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Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease.
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because only a small percentage approximately 13 of a dose of digoxin undergoes metabolism, hepatic impairment would not be expected to significantly alter the pharmacokinetics of digoxin.