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However, almost all of these patients had chronic digoxin toxicity.

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in adults, high doses of digoxin may produce a variety of electrocardiographic changes and rhythm disturbances, such as first-degree, second-degree wenckebach , or third-degree heart block including asystole ; atrial tachycardia with block; av dissociation; accelerated junctional nodal rhythm; unifocal or multifocal ventricular premature contractions especially bigeminy or trigeminy ; ventricular tachycardia; and ventricular fibrillation.

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recommended starting digoxin maintenance dosage in adults and pediatric patients over 10 years old.

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